The drug rilmenidine, commonly used to treat high blood pressure, has demonstrated the ability to extend lifespan and enhance health markers in both young and old Caenorhabditis elegans worms, according to a study published in Aging Cell. The drug, previously noted for mimicking cellular effects of caloric restriction, showed similar gene activity in kidney and liver tissues of mice. The study identified the importance of the nish-1 biological signaling receptor in rilmenidine’s effectiveness, suggesting potential avenues for anti-aging interventions. While the findings are promising, further research is required to ascertain the drug’s viability for human anti-aging applications.
Source: https://onlinelibrary.wiley.com/doi/10.1111/acel.13774